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Rac1 mutants


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#1 SF_HK

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Posted 08 March 2009 - 07:45 PM

Hi,

I'm would like to know what kind of amino acid mutations to the following RAC1 constitutively active and dominant negative mutants have:

1) RAC1 V12: constitutively active
2) RAC1 17N: dominat negative

All websites just describe theri function and not what aa change?

#2 WHR

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Posted 08 March 2009 - 10:20 PM

Hi,

I'm would like to know what kind of amino acid mutations to the following RAC1 constitutively active and dominant negative mutants have:

1) RAC1 V12: constitutively active
2) RAC1 17N: dominat negative

All websites just describe theri function and not what aa change?


Doesn't it mean that the 12th or 17th aa is mutated to V or N?




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