Posted 12 February 2009 - 08:01 PM
There are 4 known members, Jarid1a (Rbp2), Jarid1b(Plu-1), Jarid1c(Smcx), Jarid1d(Smcy)
If say, I want to lower H3K4 trimethylation in cells by siRNA against these demethylase, how could it be done?
Are there studies about the compensatory effect between different members? It's not feasible to knockdown all 4 of them and I am not sure if knocking down one of them would have any effect to overall H3K4me3 at all
Posted 15 February 2009 - 01:36 PM
Posted 15 February 2009 - 07:33 PM
Sorry, the question was wrong...
I want to increase H3K4 trimethylation