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Sox2 and neuron differentiation


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#1 p450

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Posted 10 February 2009 - 02:17 PM

Dose any one know if Sox2 is "turn off" in the neural stem cell, will the stem cell differentiate into cells other than neurons?

Thank you!


#2 Jon Moulton

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Posted 25 February 2009 - 09:27 AM

This is as close as I could get:
Rogers CD, Harafuji N, Cunningham DD, Archer T, Casey ES. Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives. Mech Dev. 2008 Oct 17. [Epub ahead of print]
http://www.ncbi.nlm....pubmed/18992330

And here's some more recent data on regulation of sox2:
Feijóo CG, Saldias MP, De la Paz JF, Gómez-Skarmeta JL, Allende ML. Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. Mol Cell Neurosci. 2008 Dec 6. [Epub ahead of print]

The straightforward approach might be to knock down Sox2 in neural stem cells and see how they differentiate.

Edited by Jon Moulton, 25 February 2009 - 09:27 AM.

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#3 p450

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Posted 25 February 2009 - 01:33 PM

Thanks, Jon!


This is as close as I could get:
Rogers CD, Harafuji N, Cunningham DD, Archer T, Casey ES. Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives. Mech Dev. 2008 Oct 17. [Epub ahead of print]
http://www.ncbi.nlm....pubmed/18992330

And here's some more recent data on regulation of sox2:
Feijóo CG, Saldias MP, De la Paz JF, Gómez-Skarmeta JL, Allende ML. Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. Mol Cell Neurosci. 2008 Dec 6. [Epub ahead of print]

The straightforward approach might be to knock down Sox2 in neural stem cells and see how they differentiate.






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