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Tumor cells immortal?


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4 replies to this topic

#1 searcher

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Posted 25 March 2005 - 11:04 AM

It says that cancer cells are immortal cells, and i wonder if i extract my cells from a tumor would these cells be immortal or mortal? <_<



Thanks.

#2 fred_33

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Posted 29 March 2005 - 12:34 AM

hi
they may be immortal. But only the cell culture will tell the truth...

For immortalized properties, cell should
be independent of growth factors to divide them
be independant of matrix attachment
have an hyperactive telomerase (if not they divide them until crisis where they are quite quiescent).
That are three basics properties of immortal cells.
But there are other cell lines that are immortal and must adhere little to plate for efficient division (such Hek 293 cells)

#3 ajames

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Posted 29 March 2005 - 10:07 PM

The cells may be immortal but they may not grow in tissue culture. Cancer cells are generally immortal(-depends on your definition) when grown under the "right conditions". Growing in a TC flask is a very artificial place for a human (derived) cell to find itself and most will not grow under these conditions.

#4 ajames

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Posted 29 March 2005 - 10:11 PM

Sorry me again. Forgot to add that I think Fred_33 (no offense) may be confusing immortaliy with a Transformed phenotype? A cell can be immortal and still require growth factors and matrix attachement. Totally agree with the telomerase though.

#5 fred_33

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Posted 29 March 2005 - 11:54 PM

hi
yep i made a mistake and would say that they can grow without having strong contacts with other cells, and at best, they can form clones (1 cell alone keep the power of dividing herself).
I'm sincerely sorry for that mistake...

Edited by fred_33, 29 March 2005 - 11:55 PM.





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