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What drives Positive Gibbs steps of Glycolysis with no ATP ?

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#1 MeetMeAtTheKrebsCycle



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Posted 19 April 2022 - 06:58 AM



I am trying to figure out something and am stuck.  The delta G of various steps are positive, so I am trying to figure out the energy input that drives the catalysis in such a step.  For example, specifically, Phosphoglyceromutase which basically moved the phosphate group one carbon (actually swaps carbons with a Phosphate at a His active site)-- nevertheless, the Gibbs free energy is positive yet no ATP used.  In fact there are several steps of the process that do NOT use ATP yet are a positive Gibbs value. 


Can someone please clearly elucidate how this happens.  I understand how glycolysis and Krebs processes are like rolling a rock up a small hill only to have the rock then fall down a massive mountain-- so I understand how there is energy in the bonds that are released that drive ATP and NADH and FADH2 production, but those I believe have a negative Gibbs.


The "uphill" reactions I am not understanding.


Can you also explain the attached graphs


Thank you for the help.



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