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minor risk allele

GWAS studies

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#1 SF_HK

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Posted 31 May 2020 - 07:16 PM

Hi, Im new to GWAS studies and would appreciate any help in understanding risk alleles associated with diseases.

 

kindly refer to the attached figure

 

In the above table for PNPLA3: G is the risk allele. GC and GG genotypes were significantly associated with increased risk of NAFLD. Is this because more samples with NAFLD have G allele compared to healthy samples and this difference is significant?

 

Also, is the risk higher (more significant) with GG than with GC genotype for NAFLD?

 

Thank you



#2 SF_HK

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Posted 31 May 2020 - 07:22 PM

The above is referring to table 2 from this link:  https://www.frontier...-00140-t002.jpg

 

From ref: Wang X, Liu Z, Wang K, Wang Z, Sun X, Zhong L, Deng G, Song G, Sun B, Peng Z and Liu W (2016) Additive Effects of the Risk Alleles of PNPLA3 and TM6SF2 on Non-alcoholic Fatty Liver Disease (NAFLD) in a Chinese Population. Front. Genet. 7:140. doi: 10.3389/fgene.2016.00140






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