Im new to SNPs. Would appreciate if someone can help me understand a few concepts on SNPs.
1. What doe sit mean when research papers mention for e.g. minor allele 'T' is a risk allele for rsxxxx (C>T). So does this imply risk for homozygous for TT and risk for heterozygous CT, but no risk for CC?
2. If rsxxx (C>T) is studied by taqman PCR, the vic/fam dyes would be for C or T. A SNP is classified if present in more than certain percentage of the population. Can someone have A or G instead of CT for this particular SNP, in which case there would be do data determined by qPCR?
Thank you, I would appreciate any help.