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Nucleotide access to core in dsRNA viruses??

Reovirus Nucleotides Core

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#1 JaredbGaut

JaredbGaut

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Posted 28 May 2018 - 04:52 PM

I'm only an undergrad, but the concept of transcription of Reoviruses taking place entirely within the core capsid of the virus is confusing.

 

How do nucleotides access the fixated RNA polymerase if its mostly closed off? I know that some viruses will be partially degraded, but if the genome is exposed enough to gain access to sufficient nucleotides, wouldn't it set off an immune response as well? (Interferon cascade, etc.)??? Do they enter through the lambda2 channel? Is there some kind of pore mechanism at work? I can't find an answer.

 

Thank you if anyone responds!


Edited by JaredbGaut, 28 May 2018 - 04:53 PM.





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