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Genexpression of overlapping genes

gene overlapping sequence expression

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#1 Manaka



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Posted 06 April 2018 - 12:29 AM

Hello everybody! 


I'm on the quest to find out why, when studying a certain gene, another gene is always being mentioned as well in it's expression. 


As it seems, the gene (MIR-6734) which always occurs when speaking of the main gene (ELOVL1), is sitting in the ELOVL1 gene, or is at least overlapping. (see file) 


Since I found no connection between the two genes in their function, but only in their localization, I assume the MIR gene is only mentioned because it is always expressed as well, when the ELOVL gene is being expressed. 


Does anyone have an idea why their expression seems to be coupled? Or why sometimes instead of the ELOVL1 gene, just the MIR6734 is mentioned, almost like synonyms for each other?




Thank you very much for ideas, infos and help! 

Attached Thumbnails

  • ELOVL1 mir.png

Edited by Manaka, 06 April 2018 - 12:30 AM.

#2 bob1


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Posted 06 April 2018 - 06:11 AM

Like we mentioned before the MIR-6734 is NOT a gene, it is a small interfering RNA and hence is not expressed, it is however, transcribed! It is not a synonym for ELOVL1 either. I suspect that because of the location in the coding sequence for ELOVL1, that it is transcribed at the same time as the ELOVL1 gene. 


If I were you I would be looking at mechanisms for miRNA transcription - it seems likely that these particular ones are coupled, and that this is a common mechanism.

#3 Manaka



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Posted 07 April 2018 - 12:38 AM

Thank you very much for your help again! 


I'll surely do that! 

Also tagged with one or more of these keywords: gene, overlapping, sequence, expression

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