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What are the side-effects of CAR T therapy?

car t therapy cancer

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2 replies to this topic

#1 Bella Smith

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Posted 30 March 2018 - 03:03 AM

The chimeric antigen receptors (CARs) consist of an extracellular antigen recognition domain (usually a single-chain antibody, but also a polypeptide or other protein) and an intracellular signal domain. The extracellular portion of CAR is used to identify specific tumor antigens, and the intracellular signal domain then stimulates T cell proliferation and eliminates tumor cells by cell lysis and cytokine release. 



#2 Rnotk

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Posted 08 April 2018 - 09:38 AM

Cytokine storm syndrome and neurotoxicity could be a potential side effect. so patient immunity needs to be monitored pre-/post-treatment.



#3 aimikins

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Posted 11 April 2018 - 03:04 PM

depending on your disease model/patient case history, tumor lysis syndrome may also be an issue.


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