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Can a siRNA derived from hairpin structure just like miRNA?

siRNA miRNA hairpin

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#1 Corey

Corey

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Posted 11 April 2017 - 06:04 AM

Hi everyone, nice to meet everybody in here, I got a simple question.

As far as I know, miRNA is derived from the long ssRNA sequence which can form a hairpin. And by introducing a specifically modified sequence which has 2 inverted tandem sequence flanking its both end, we can artificial create a hairpin which will then be processed by dicer and combine with AGO and form into a siRNA.

However, does organisms naturally possess any pathway or mechanism that can create siRNA via hairpin???

 

Thank you everyone for paying attention to my question.







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