I have two questions, first, how does the human long non coding RNA (lnc-RNA) changes the gene expression epigenetic marks and how can it target a particular cell for delivery?
To being with, lizard has the power to regenerate limbs, the lizard macrophages turn the cells in the wounded area into blastemal cells then send in microRNA to pattern these blastemal cells into a new limb. This proves that microRNA is capable of causing a cell to specialize, or changes the gene expression of the cell. In the human it is terms lnc-RNA and it is a newly discovered method in modifying the epigenetic marks. I would like to know how the human lnc-RNA changes the gene expression with the epigenetic marks using its codes.
Edit: To see whether microRNA can produce the type of methyltransferase required we need to know where methytransferase is produced
I would also like to know how lnc-RNA could target a particular cell. Every cell has a different epigenetic mark due to its shape and specialization. It would be cool to know how the lnc-RNA could target a particular cell based on the cell's epigenetic marks. This is speculation on my part.
Edit: There are attempts in finding the microRNA target prediction, but it is not 100% accurate
There might not be an immediate answer for the two questions, but hopefully we can theorize a method or discover new answers as time goes on.
Edited by Fredreload, 21 March 2017 - 07:02 AM.