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MTHFR 1298 legit? does Dr. Lynch theory make sense?

Lynch methylation mthfr 1298 677

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#1 vaarmen

vaarmen

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Posted 05 August 2016 - 02:14 AM

How is MTHFR 1298 involved in BH2 -> BH4 conversion?

 

‹‹Would appreciate comments on the following.

 

1) MTHFR 1298 is an SNP on the MTHFR gene which encodes the MTHFR enzyme only.

2) MTHFR enzyme is not involved in BH2 -> BH4 conversion

3) Even if methyl folate is required for the BH2 -> BH4 conversion that does not make the 1298 SNP any special. Similarly, the 677 SNP would make the conversion hard because of deficiency on MethylFolate. Is there anything wrong with the above points? Thanks in advance!







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