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Can microglia stain positive for phagocytosed material?


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#1 neuropath

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Posted 30 May 2016 - 07:32 PM

Hello Bioforumers,

 

Does anyone know if it is possible for microglia to become immunoreactive for antigens that they have phagocytosed? I performed xenotransplantation of human cells into mouse brains and found some microglia to be positive for human-specific antigens. 

 

Thanks in advance happy.png .

 

~neuropath~



#2 Trof

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Posted 02 June 2016 - 11:39 AM

Well, microglia are APCs, so I would expect them to partially digest and present on the surface everything they encounter. 


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#3 neuropath

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Posted 13 October 2016 - 04:52 PM

Well, microglia are APCs, so I would expect them to partially digest and present on the surface everything they encounter. 

Thanks for your reply Trof.






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