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B & T cell activation in autoimmune disorders


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#1 microbiogeek15

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Posted 16 March 2016 - 12:27 AM

So, I know that B cells need T cell help for proper activation and isotope class switching. But, in some autoimmune diseases (such as Rheumatoid arthritis) antibodies are produced of the IgG isotope that are specific for DNA. DNA cannot be presented to MHCs on B cells, therefore it cannot be presented to T cells either. So how exactly would you get an auto immune response? Anyone have any ideas to explaining this phenomena?

 

Any help/insight would be much appreciated



#2 Zoe Winslet

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Posted 14 June 2016 - 07:39 PM

This autoimmunity article may help yourolleyes.gif smile.png smile.png smile.png smile.png 

 

http://www.creative-diagnostics.com/Autoimmunity.htm


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