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Migration of circular DNA vs circular/crosslinked peptide in gels


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#1 labtastic

labtastic

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Posted 11 August 2015 - 12:54 PM

As I understand it:

 

1. Relaxed circular DNA migrates slower on a gel than linearized DNA (e.g. here)

 

2. Circular peptides (or intra-crosslinked peptides) run faster on a gel than linearized peptide

 

--> So circular DNA runs slower and circular peptides run faster than their linear counterparts.

 

 

Why the difference? 


Edited by labtastic, 11 August 2015 - 05:33 PM.





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