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Is there always a presence of activated T cells in a healthy host?

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#1 Ahrenhase



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Posted 18 December 2014 - 09:41 PM

I understand that after and immunogenic response, you get T cell activation (marked by CD69 and CD25 expression), and that activated T cell numbers contract after a while.  My question is that if you were to pull blood from a healthy individual  and not include CD25+ Tregs in your analysis, would you expect to see CD25+ or CD69+ activated T cells?

Edited by Ahrenhase, 18 December 2014 - 09:42 PM.

#2 bob1


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Posted 19 December 2014 - 01:43 AM

Not being an immunologist, I may be completely wrong here:


My thoughts are - yes, you should. The body is constantly under assault by all sorts of antigens (e.g. in the gut and nasal passages), so there should be a small population of activated T cells all the time.

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