I am reading the following paper: Development and characterization of an enhanced nonviral

Posted 30 August 2014 - 07:20 AM
I am reading the following paper: Development and characterization of an enhanced nonviral
Posted 30 August 2014 - 03:53 PM
The presence of the "p" in pEEV and the non-viral vector are the hints here - this is a plasmid not a virus.
Posted 31 August 2014 - 12:38 AM
The presence of the "p" in pEEV and the non-viral vector are the hints here - this is a plasmid not a virus.
i get that. but they say because they utilized viral components, they tested for oncolytic activity. so i am asking how excessive gene expression causes oncolytic activity. in cancer cells that are ever growing is there no excessive gene expression already? im not sure what exactly happens in cancer cells hence the confusion
Posted 31 August 2014 - 12:51 PM
The components might be very stong promoters, which would induce continuous high gene expression independent of the cell cycle.
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