I plan to incorporate BrdU into the DNA of my proliferating human cells in culture, isolate the DNA and IP with an anti-BrdU antibody to capture those DNA sequences. I am wondering the disadvantages/advantages of using Dynabeads with either Protein G or sheep anti-mouse to capture the mouse anti-BrdU:DNA(BrdU) compexes? Specificity? Sensitivity? Efficiency? I feel that the two would be almost equal but I am not sure, which is why I am posting this question.