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In vitro therapeutic index

Medicinal Chemistry in vitro antibiotics therapeutic index

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#1 Davie057

Davie057

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Posted 24 April 2014 - 08:52 AM

Hi,

 

I was wondering if anyone know what the requirements are for the therapeutic index of antibiotics under development.

I calculate the therapeutic index (TI) of my compounds as IC50/MIC (Lethal concentration at which the viability of eukariotic cells is reduced by 50% divided by the minimal inhibitory concentration against the bacteria). As a result I end up with a (TI) around 100 to 500.

However I was wandering which threshold do pharmaceutical companies hold for antibiotics under development? Does anyone have an idea? I can't find an answer on the net.

 

All the best,

 

Davie







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