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Can an protein be tolerized against if it doesn't have an MHCII epitope?

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#1 Ahrenhase



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Posted 04 March 2014 - 02:45 PM

In the classical paradigm of immunological tolerance, the majority of Tregs develop within the thymus upon presentation of MHCII epitopes from mTECs and medullary DCs. Does this mean that if a protein in the periphery doesn't have an MHCII epitope, then it can't be tolerized against?

#2 Tabaluga


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Posted 04 March 2014 - 05:25 PM

Not sure that i understood the question correctly.
Tolerance can be induced against a protein without MHCII. T cells undergo positive selection in the thymus in that they only survive when they bind strongly enough to MHC I or MHC II (CD8 and CD4 positive T cells respectively), and negative selection in that they only survive when they do not bind strongly to the self-antigens ectopically expressed by mTECs and DCs. IIRC T regs are supposed to have an intermediate affinity here, although I'm not sure if this is just a theory or already proven.

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