Thanks to everyone who has helped me produce stable DNA from assorted mouse tissues to be eventually be used for a southern blot experiment. I've attached a gel picture that shows 14 different undgiested genomic DNA samples that were isolated from mouse tissue. In my opinion, all the DNA samples are fine to continue with Southern, except #4 and #12. Each shows a fairly strong parent band, with minimal degradation underneath. Is this conclusion correct or do you think the faint smears are a concern?