The case of JAK kinases (initially called 'Just another kinase, hahahah!' later, when it was found, mutation in JAK2 causes serious condition, renamed to 'Janus kinase' to fix the embarassment) and RING finger domain (where the RING apparently stands for 'really interesting new gene') get me the idea of topic for posting funny names of genes, proteins, domains.. stuff..
I knew before, that fly scientists have a weird sense of humor.. naming Drosophila genes first by the phenotype they caused (like wingless), which is fairly understandable, but later just naming them.. weird.. like even-skipped, fushi tarazu (which should mean something like odd-skipped in japanese) and sonic hedgehog.
Sadly for us, these names survived into human homologues too
I found this link with some other "funny names".
Do you know any more?