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Will SPRI beads bind my nucleosomes?

SPRI beads Beckman Coulter Nucleosome Histones ChIP

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#1 ss00



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Posted 03 August 2013 - 03:27 AM

Hi all,


I want to purify my nucleosomes after MNase digestion using SPRI beads. I know SPRI beads bind DNA but my question is will my SPRI beads bind the DNA while its bound to histones or will I only bind the DNA and leave the histones behind? 



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