2 replies to this topic

[Krikezz]

And why not using EPSP amplitude ? When they measure LTP they always use EPSP slope why is that and what is it ? Also what is EPSP spike compared to amplitude and slope ?

Thanks'

Edited by Krikezz, 05 June 2013 - 07:55 AM.

[Inmost sun]

it is more convincing to show both, amplitude and slope, because each parameter can change independenty from the other but in the case of LTP both should be increased

[Mahati Krishna]

The EPSP slope in an extracellular field recording is usually taken as the first one-third of the fEPSP. The slope value is preferred over the amplitude or other measures because at a higer current intensity (or if the electrodes are places too close to the cell bodies), the pEPSP is likely to be contaminated by the occurance of a pop spike and that can change the amplitude but not the slope.