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Depleting circulating IgE effects on allergic reaction.

IgE Allergies mast cells peanut immunology

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#1 RubyViolet

RubyViolet

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Posted 05 April 2013 - 06:37 PM


I was reading this article : http://www.medscape....ticle/777380_10 but quickly became confused where it said "The complexes of anti-IgE bound to IgE are then cleared from the circulation. Thus, activation of allergic responses, at least to small amounts of peanut protein, can be prevented."

I was wondering if someone could explain to me how reducing circulating IgE concentrations affect the response for peanut allergy. Since the IgE involved in peanut allergy is bound to mast cells by its Fc region, I was wondering if after allergic reactions mast cell numbers are decreased and hence need to make more peanut specific IgE to present on their cell surface.


Can anyone help?






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