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[SF_HK]

Hi,

I've never worked with mouse models but have to plan for one and would appreciate any advice.

I looking to develop a mouse model that forms HCC after cirrhosis.  I've read a few papers and most use CCL4.  Has anyone used  this treatment and if so:

1. howl ong doe sit to take to develop cirrhosis
2. how long doe sit take to develop HCC following cirrhosis
3. the % of survical of mice. Can teh mice survive til the development of HCC
4. Is this a harsh treatment?

Many thanks

[Curtis]

I found some old Italian papers, might be helpful?

http://www.ncbi.nlm..../pubmed/7959573
http://www.ncbi.nlm..../pubmed/8358289