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Adenovirus for protease inhibitor studies.


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#1 bluebird

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Posted 22 January 2013 - 04:34 PM

Hi
I am trying to test HCV protease inhibitor on NS3 protein expressed in adenovirus vector. I discovered lately that adenovirus has AVP(cysteine protease) which has charcters similar to NS3 protease, do you think this will interfere with my results?

#2 bob1

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Posted 23 January 2013 - 12:42 AM

Depending on the variant of Ad you use, the cys-protease may have been deleted. You could try expressing the NS3 off a plasmid?




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