1 reply to this topic

[mekelseyb]

I am looking for a target gene, that when knocked down by siRNA will cause apoptosis. I have searched the literature and have yet to find anything that might be helpful.

I did find a apoptosis inducing siRNA produced by Altogene. They claim it will cause apoptosis in all cell lines. Any idea what their target might be?

Thanks!

[bob1]

You could try MDM2 KD.  MDM2 is the negative regulator of p53, high levels of p53 should induce apoptosis.