Jump to content

  • Log in with Facebook Log in with Twitter Log in with Windows Live Log In with Google      Sign In   
  • Create Account

Submit your paper to J Biol Methods today!
Photo
- - - - -

Use female BALB/c nude mice in HCC study

HCC nude mice BALB/c

  • Please log in to reply
2 replies to this topic

#1 kblee

kblee

    member

  • Active Members
  • Pip
  • 15 posts
0
Neutral

Posted 14 January 2013 - 07:57 PM

Dear all,

Can anyone tell me why use female BALB/c nude mice in HCC study of TCF factor? Any particular reason not using male mice instead?
As papers I read mainly use male nude mice on HCC study.

Thanks all!

#2 leelee

leelee

    Veteran

  • Active Members
  • PipPipPipPipPipPipPipPipPipPip
  • 652 posts
52
Excellent

Posted 14 January 2013 - 09:49 PM

Some reasons might be that female mice tend to get along with each other better (don't fight and injure each other as much), and are often easier to handle.

#3 leelee

leelee

    Veteran

  • Active Members
  • PipPipPipPipPipPipPipPipPipPip
  • 652 posts
52
Excellent

Posted 14 January 2013 - 09:55 PM

A quick google search leads me to find that it is better to use male mice rather than female, as a model for HCC, because oestrogens can inhibit HCC formation, while adrogens stimulate it.

So I'm not sure it is advisable to use female mice- as less will develop the HCC for you to study.

Unless the gender specific differences is what you are interested in maybe?





Also tagged with one or more of these keywords: HCC, nude mice, BALB/c

Home - About - Terms of Service - Privacy - Contact Us

©1999-2013 Protocol Online, All rights reserved.