2 replies to this topic

[kblee]

Dear all,

Can anyone tell me why use female BALB/c nude mice in HCC study of TCF factor? Any particular reason not using male mice instead?
As papers I read mainly use male nude mice on HCC study.

Thanks all!

[leelee]

Some reasons might be that female mice tend to get along with each other better (don't fight and injure each other as much), and are often easier to handle.

[leelee]

A quick google search leads me to find that it is better to use male mice rather than female, as a model for HCC, because oestrogens can inhibit HCC formation, while adrogens stimulate it.

So I'm not sure it is advisable to use female mice- as less will develop the HCC for you to study.

Unless the gender specific differences is what you are interested in maybe?