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RAG-KO vs. Prkdc^scid mice

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#1 gloinddark



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Posted 02 January 2013 - 12:21 AM

Hi there,

I would like to know the difference between RAG-KO mice and Prkdcscid mice, with respect to their immune system. I think I am missing something. Apologies if these are basic questions.
Are Prkdcscid mice deficient in DNA-PK?
Is it correct to say that both RAG and DNA-PK are involved in VDJ recombination, so both mice models have the same T and B cell deficiency?

Thank you Posted Image

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