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[shashwati]

Hi all,

I've been looking for the rate of blood flow in the human peritoneum in order to obtain a range of physiological shear stress values, for a set of protein-ligand interaction studies I have to do later on in my project (this is to do with ovarian cancer cells binding with mesothelial cells in the peritoneum).

However, I've been finding conflicting and confusing information in papers, and the vast majority are to do with peritoneal dialysis.

The figures I've seen most often are around 60-100 ml/min, but I've seen different rates based on clearance of different molecules.

Could someone tell me more about this, and provide me with a physiological range of shear stresses experienced in the peritoneum due to blood flow and/or lymph flow? Either of the figures (dynes/cm² shear stress, or ml/min blood flow rate) I would appreciate references to accepted studies about this too.

Thanks a lot,
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Shashwati Kala