removing MHC class I from the cell surface
Posted 31 October 2012 - 07:48 PM
Does anyone know if it is possible to strip MHC class I molecules from the surface of cells (enzymatically, chemically, whatever...)?
I'm having a hard time finding any information on this, as every search I perform comes up with info on stripping the peptides from the mhc I molecules, but not the molecules themselves.
Fingers crossed one of you can help!
Posted 17 November 2012 - 06:24 PM
Hope that's helpful.
Posted 17 November 2012 - 08:05 PM
I've been told something similar just recently by a colleague too, however I think they were a bit confused and so not very clear, meaning I had a hard time finding a paper or the like to verify it. Any chance you can point me in the right direction?
Thanks for the info re BfnA and the shifting of the population to the left. I think that will be ok for my purposes, I'm really just trying to explain a certain population of cells I'm getting rather than worrying about complete removal of MHC I from the surface.