Method of chemical vagal stimulation for potentiation CNS drugsvagus potentiate
Posted 29 September 2012 - 08:54 AM
Dear Friends! Please discuss my project of potentiating CNS drugs by chemical vagal stimulation .
"method for potentiating drugs"
Electrical vagus stimulation is considered as the most effective method of treatment of such diseases as epilepsy, depression, chronic pain, drug addiction, obesity, resisted to action of drugs. However the mentioned method demands expensive operation and is not safe (it can cause cardiac arrest, bronchospasm, abdominal pains and other complications.).
I suggest safe method of the chemical stimulation of the receptors of vagal afferents by agonists of peripheral receptors: cholecystokinin (CCK), glutamate, АТP, epinephrine, phenylephrine, carbacholine and adenosine, weakly penetrating into CNS, which in small, not causing side-effects doses after systemic or oral administration selectively stimulate chemoceptors of vagal afferents. Chemical stimulation of vagal afferents by agonists of peripheral receptors eliminates pain, depression, anxiety, convulsions, hypoxia, inflammation, decreases stress and, that the most important thing, in tens and hundreds times potentiates action of analgesics, antidepressants, antiepileptics, neuroleptics, antiparkinson agents, antihypoxics agent, stress protective agents without increasing of side- effects of drugs
In contrast to expensive and unsafe method of the electrical vagus stimulation the offered method of chemical vagus stimulation is safe, cheap and accessible to patients as allows to use agonists of peripheral receptors in the standard dosage form (solutions, tablets, syrups, granules) or can be added to dosage form of known drugs.
The idea can be realised quickly enough, for two years term because the used substances are allowed to clinical application.
As a whole, the idea is devoted to the problem of creating of the simple and accessible method of chemical stimulation of vagus for the purpose of mass treatment of many diseases, and also potentiation of effects of analgesics, antidepressants, neuroleptics, antiepileptics without side-effects and complications
Posted 30 September 2012 - 12:00 AM
As far as I understand the electrical stimulation has the great advantage to be pretty specific - to vagus nerves. The side effects caused by this are due to the complex effect of the vagus nerves as same way it has the broad spectrum of possitive effects.
So you want to change this complicated but direct method having side effects resulting from the activation itself by activating the vagus nerves indirectly through weakly penetrating chemcal agents. But they are even less specific, what other kinds of receptors they react with? In addition anything weakly penetrating has to be present in blood in high concentration to even get to the brain. The way I see it you keep all the negative side effects and add many more (if I'm wrong about this, please correct me) because of the chemicals nonspecifity.
Like.. ATP, adrenalin,..really? You just want people to eat adrenalin in tablets? Most cells in body have adrenaline receptors, the effect would be massive and not directed as required. You want to treat anxiety with adrenalin? And ATP.. the first cell that come to range will snatch it, how do you want to get it to the right receptors only?
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Posted 01 October 2012 - 01:15 PM