4 replies to this topic

[timo716]

Hello everyone,

I'm a 3th year student off the university of applied science Leiden the netherlands.
(do not mind my english please )
I'm an microbiologist.
I have a research idea about antibiotics it's simple

why augmentin (amoxicilline with clavulan acid) when you maybe can use any other beta lactamase antibiotica and an inhibitor

so in theory you can disign several new antibiotics
my teachers gave me right but why don't they try it out?
or test it or something?


with kind regards timo

[bob1]

Hmmm - this is really a homework question for you - some hints are synergy, additive and antagonistic.

[drwho]

I agree with the above post. I think  you are on the right track.

I would suggest you ask your self why augmentin is used think out how its composition is related to its use. One of the best lessons I was ever taught was "how does structure relate to functions" if you keep this in mind you will do very well. Always ask this question

[prabhubct]

timo716, on 23 September 2012 - 09:53 AM, said:

why augmentin (amoxicilline with clavulan acid) when you maybe can use any other beta lactamase antibiotica and an inhibitor

In antibiotic broad spectrum (A broad-spectrum antibiotic acts against both Gram-positive and Gram-negative bacteria) and narrow spectrum antibiotics are groups. Amoxicillin comes under broad spectrum antibiotics so it can cure wide range of infections by acting against many bacteria. amoxicillin resistance is due to beta lactamase production in bacteria. clavulanic acid is suicide inhibitor for beta-lactamase. Hence amoxicillin /clavulanic acid combination is used.


Now to your actual question- what combination you are intending to use? is antibiotic u r using is broad spectrum or not? what inhibitor u r using? Is there study showing interaction between antibiotic and inhibitor? are they compatible(additive, synergistic) or antagonistic?

Edited by prabhubct, 29 September 2012 - 11:21 PM.

[Dan Faggella]

prabhubct, on 29 September 2012 - 09:47 PM, said:

timo716, on 23 September 2012 - 09:53 AM, said:

why augmentin (amoxicilline with clavulan acid) when you maybe can use any other beta lactamase antibiotica and an inhibitor

In antibiotic broad spectrum (A broad-spectrum antibiotic acts against both Gram-positive and Gram-negative bacteria) and narrow spectrum antibiotics are groups. Amoxicillin comes under broad spectrum antibiotics so it can cure wide range of infections by acting against many bacteria. amoxicillin resistance is due to beta lactamase production in bacteria. clavulanic acid is suicide inhibitor for beta-lactamase. Hence amoxicillin /clavulanic acid combination is used.


Now to your actual question- what combination you are intending to use? is antibiotic u r using is broad spectrum or not? what inhibitor u r using? Is there study showing interaction between antibiotic and inhibitor? are they compatible(additive, synergistic) or antagonistic?

Agreed. Important question to consider.