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[jay99]

I have noted different dapi profiles in the nucleus of mammalian cells. A recurent profile is bright spots over a fainter background (especially seen in liver). Do these spots correlate with heterochromatin because of condensation of DNA ?
I would appreciate any hints regarding this matter,
Thanks

[Victor]

Yes, but that's not enough to conclude that it's heterochromatin.  If it colocalizes with histone antibodies (by fluorescence or immuno EM), then you'll have more substantial evidence.