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Inhibition P450 BM3 FAD/NADPH domain?

Started by Spook, Jul 27 2012 09:18 AM
P450 BM3 CYP102A1 FAD/NADPH

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#1 Spook

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Posted 27 July 2012 - 09:18 AM

Hi,

I'm doing some research on CYP P450 BM3, but I am wondering why all inhibitors act on the heme group. Isn't it also possible to inhibit the FAD/NADPH domain by an inhibitor that competes with NADPH for binding to the FAD so that NADPH, the cofactor, can not bind and thus it can not act as a monooxygenase?
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