Am I correct to say that all mRNA will be translated into protein provided they have the 5' cap and Poly-A tails? Or what is the best reason to support that all mRNA translated into protein?
From what i think is:
- The cells wont waste energy if they transcribed mRNA but not translated into protein.
Can anyone enlighten me?
0
2 replies to this topic
#2
bob1
-
- Global Moderators
-
- 4,350 posts
Thelymitra pulchella
224
Excellent
Excellent
Posted 19 May 2012 - 03:54 PM
Not entirely true, there are many mRNAs that do not have poly A tails. There is also evidence that the cell can hold some mRNA in a pool for later use, especially for stress response proteins IIRC.
#3
doxorubicin
-
- Moderators
-
- 147 posts
Veteran
7
Neutral
Neutral
Posted 22 May 2012 - 06:31 AM
Here's an article on nonsense mediated decay and the pioneer round of translation: http://www.sciencedi...092867410008263
Cells often will make mRNAs with premature stop codons which need to be destoyed. Of course the pioneer round of translation will have made a truncated peptide, so technically translation has occurred, but no full length protein was produced, hence net waste of energy.
Cells often will make mRNAs with premature stop codons which need to be destoyed. Of course the pioneer round of translation will have made a truncated peptide, so technically translation has occurred, but no full length protein was produced, hence net waste of energy.
