No replies to this topic

[Shifting Reality]

Hello

miRZiP anti-sense microRNAs are stably expressed RNAi hairpins that have anti-microRNA activity.The
miRZip shRNAs produce short, single-stranded anti-microRNAs that competitively bind their endogenous
microRNA target and inhibit its function. Because these are short hairpins, I assume that a hairpin was processed by the Dicer so the anti-sense strand can incorporate to the RISC complex. Does anybody know that how the anti-sense strand can bind to its target miRNA if the anti-sense strand can be found in the RISC complex?

SF