Functional relationships between genes that are contiguous in the genome
Posted 04 April 2012 - 09:06 AM
I started a thread about this subject about one year ago but I can't find it.
I am studying a gene whose function is not described (let's call it gene "Y"). The protein possesses a domain that is found in some transcription factors of the zinc cluster family although no DNA binding domain is found by bioinformatics. In oppostion to the wild type, the knockout mutant for this protein is unable to induce some genes (when cells are treated with a stress) confirming that it is a transcriptional regulator. Interestingly, one of these genes that the mutant is unable to induce (gene "Z") is adjacent to "Y" in the genome (downstream), suggesting some sort of relationship between two genes that are contiguous in the genome. Another coincidence (or maybe not...) is that the gene immediately before in the genome ("X") contains a zinc finger domain known as a binding region for DNA and RNA. However, I could not find so far any functional relationship between X and Y.
I believe that some sort of interesting mechanism of regulation is occurring but since this is not a subject that I am very familiar with, I don't know very well how to approach the problem.
Is anyone aware of such gene relationships?
Posted 09 April 2012 - 11:59 AM
Posted 10 April 2012 - 03:14 AM
Yes, I am talking about eukaryotic cells (I work with a fungus). I did a little paper research about eukaryotic operons and found some interesting articles. I'll take a look at them.