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Please explain me the use of congenic strains


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4 replies to this topic

#1 vidyadharn

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Posted 08 January 2012 - 05:53 PM

Hi all what are the uses of congenic mouse strains? Please explain me with one example.thank you

#2 bob1

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Posted 10 January 2012 - 12:40 PM

Hmmm homework? How about you tell us what you know and then we will help you with your answers.

#3 vidyadharn

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Posted 11 January 2012 - 12:47 AM

Normally they are used to know the function of an unknown gene.why should we produce congenic strains to know the function of a gene.why can't we know the function of a gene in originl strain itself. What is the advantage and methodology.

It's not my home work but my self work.thank you

#4 bob1

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Posted 11 January 2012 - 02:21 PM

You can work on the function of the gene in the original strain, but with the congenic you have only the region/gene changed in the recipient, so that you can assume that any changes from the parent recipeint strain are due to the changed region/gene, making it easier to determine the function of the region/gene in a functional manner.

#5 vidyadharn

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Posted 12 January 2012 - 06:59 AM

Thank you bob .my idea matched with your explanation




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