4 replies to this topic

[vidyadharn]

Hi all what are the uses of congenic mouse strains? Please explain me with one example.thank you

[bob1]

Hmmm homework?  How about you tell us what you know and then we will help you with your answers.

[vidyadharn]

Normally they are used to know the function of an unknown gene.why should we  produce congenic strains to know the function of a gene.why can't we know the function of a gene in originl strain itself. What is the advantage and methodology.

It's not my home work but my self work.thank you

[bob1]

You can work on the function of the gene in the original strain, but with the congenic you have only the region/gene changed in the recipient, so that you can assume that any changes from the parent recipeint strain are due to the changed region/gene, making it easier to determine the function of the region/gene in a functional manner.

[vidyadharn]

Thank you bob .my idea matched with your explanation