Basically I've had to do some Bioinformatic work recently having never ever done or even heard of the subject before, so I'm a complete novice as to how to use all the websites like NCBI, Vega Sanger, BLAST, BLAT... etc.! and I'm finding it really hard to understand exactly what it is that I'm looking at.
I've been trying to find the number of polymorphisms in a particular gene, human TRIM5. I found one website with it on http://www.uniprot.org/uniprot/Q9C035 and simply counted the 'Natural Variants' to come up with a number of 10. However, I would be really grateful if anybody could give me some guidance. Are these natural variants actually the same as polymorphisms? Have I actually managed to include all of the polymorphisms (if they are indeed 'natural variants') or am I accidentally only looking at a subset of polymorphisms?
Just to re-iterate the fact that I really feel out in deep water with this subject and so if you do give any answers please feel free to phrase any reply as if I'm a little bit stupid! I really want to understand what all these things are, feeling lost is a very horrible feeling!
Any help would be MUCH appreciated.
Thanks in advance!
Edited by seaholme, 06 January 2012 - 07:07 AM.