4 replies to this topic

[DDLJ]

What is the difference between Polymorphism and SNP? And because of which one of thez two, is responsible for diseases?

[pcrman]

SNP is just one type of polymorphism and involves only one nucleotide. Any type polymorphiism can be associated with disease.

[DDLJ]

But it is becoz of polymorphism only, each individual differ from each other, then how polymorphism contributing to diseases.

Edited by emailsonica, 31 December 2011 - 08:51 AM.

[Felipillo]

You should read this paper  Genetic Variation.pdf (118.64K)
Number of downloads: 15

[pito]

DDLJ, on 31 December 2011 - 08:50 AM, said:

But it is becoz of polymorphism only, each individual differ from each other, then how polymorphism contributing to diseases.

1. SNP is a type of polymorphism
2. polymorphism just means that the DNA is "different" due to a mutation for example, a base switch (T and not G for example at a certain place)
3. I think its clear that when you normally have GATC and due to a SNP you have all of a sudden AATC that this change in sequence can cause a disease..
(another example: take for example a SNP in a gene coding for a protein and because of this SNP you get a stop codon rather then a codon for an AA , then what happens? translation will stop and you will not form that protein.. result: disease (or not, its not always the worst case scenario ofcourse)

And that paper might help indeed.