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[neuron]

Hi,

Is there any known phenomena where knocking out two genes can nullify the effect of single knock outs of both the genes? What I mean here is that we have two different knock out strains, both show defects but when you knock out both the genes the strain overcome the defect and behaves like wild type strain . I searched about this and came across to only epistasis, however in epistasis the defects in double mutant should be similar to epistatic gene. and that is not true in my case. Is anyone aware of this phenomena in any system, or am I missing some basic understanding about genetics?....please help