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mutation in both the genes nullify the defects

what do we call it?

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#1 neuron

neuron

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Posted 14 December 2011 - 02:31 AM

Hi,

Is there any known phenomena where knocking out two genes can nullify the effect of single knock outs of both the genes?Posted Image What I mean here is that we have two different knock out strains, both show defects but when you knock out both the genes the strain overcome the defect and behaves like wild type strainPosted Image . I searched about this and came across to only epistasis, however in epistasis the defects in double mutant should be similar to epistatic gene. and that is not true in my case. Is anyone aware of this phenomena in any system, or am I missing some basic understanding about genetics?....please helpPosted Image




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