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question about building a simulated translocated chromosome

chromosome translocation

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#1 JoanManuel

JoanManuel

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Posted 15 November 2011 - 03:54 PM

Hi:
I would like to construct a philadelphia chromosome based on the FASTA sequences of chromosome 9 and 22, the procedure is done according to the following figure:
Posted Image

in which the BCR part of chromosome 22 joins with the ABL part of chromosome 9 and creates a changed chromosome 22, I have downloaded the fasta sequences of chromosome 9 and 22, also the parts that deals with BCR and ABL; the question that I have is how I can make the join using the fasta sequences to build a philadelphia chromosome?





Also tagged with one or more of these keywords: chromosome, translocation

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