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Any reliable markers for mouse memoery T cells?

immunology FACS memory cells cell separation

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#1 tk2509



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Posted 25 October 2011 - 11:53 PM

Hi all,

I'm looking for markers of murine memory CD4 cells for FACS. There are many genes that correlate with this population but still they are not memory cells-specific. Do you have any ideas or have yuo used any cell separation kit which yielded representative populations?

Many thanks!

#2 allynspear



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Posted 26 October 2011 - 05:33 AM

I asked my friend who is a Immunology Guru, and after a 20 minute discussion on whether memory T-cells actually exists, he told me this:

There are generally considered two different types of memory T-cells, Central and Effector. Central memory cells should have the CCR7 and CD62L surface markers, but effector cells generally do not. Central memory cells secrete IL-2, but Effector memory cells secrete IL-4 and IFN-gamma.

Hope this Helps!

Best of Luck.

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