Hi all,
I'm looking for markers of murine memory CD4 cells for FACS. There are many genes that correlate with this population but still they are not memory cells-specific. Do you have any ideas or have yuo used any cell separation kit which yielded representative populations?
Many thanks!
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Any reliable markers for mouse memoery T cells?
Started by tk2509, Oct 25 2011 11:53 PM
immunology FACS memory cells cell separation
1 reply to this topic
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allynspear
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Posted 26 October 2011 - 05:33 AM
I asked my friend who is a Immunology Guru, and after a 20 minute discussion on whether memory T-cells actually exists, he told me this:
There are generally considered two different types of memory T-cells, Central and Effector. Central memory cells should have the CCR7 and CD62L surface markers, but effector cells generally do not. Central memory cells secrete IL-2, but Effector memory cells secrete IL-4 and IFN-gamma.
Hope this Helps!
Best of Luck.
There are generally considered two different types of memory T-cells, Central and Effector. Central memory cells should have the CCR7 and CD62L surface markers, but effector cells generally do not. Central memory cells secrete IL-2, but Effector memory cells secrete IL-4 and IFN-gamma.
Hope this Helps!
Best of Luck.
