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Meta analysis - result interpretation

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#1 Jasmine



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Posted 08 October 2011 - 05:28 AM

Hi all,

I am working on meta analysis of a polymorphism with respect to disease X.

Lets say the wildtype is 'a' and the variant is 'A'. I have used a number of genetic models like recessive, dominant, allele contrast and homozygous models.

The results i get are as follows: a significant association seen for recessive genetic model but not for any other model.

My query here is:

i) Is my interpreatation of results correct:
the homozygous variant genotype (AA) has a higher risk of disease as compared to the the heterozygous and homozygous wildtype genotypes (Aa+aa)

ii) homozygous model (AA vs aa) shows no positive results. so are my results for recessive model of any significance.

Any sort of help and suggestions are welcome.

Thanks in advance,

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