I am working on meta analysis of a polymorphism with respect to disease X.
Lets say the wildtype is 'a' and the variant is 'A'. I have used a number of genetic models like recessive, dominant, allele contrast and homozygous models.
The results i get are as follows: a significant association seen for recessive genetic model but not for any other model.
My query here is:
i) Is my interpreatation of results correct:
the homozygous variant genotype (AA) has a higher risk of disease as compared to the the heterozygous and homozygous wildtype genotypes (Aa+aa)
ii) homozygous model (AA vs aa) shows no positive results. so are my results for recessive model of any significance.
Any sort of help and suggestions are welcome.
Thanks in advance,
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Meta analysis - result interpretation
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