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Meta analysis - result interpretation


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#1 Jasmine

Jasmine

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Posted 08 October 2011 - 05:28 AM

Hi all,

I am working on meta analysis of a polymorphism with respect to disease X.

Lets say the wildtype is 'a' and the variant is 'A'. I have used a number of genetic models like recessive, dominant, allele contrast and homozygous models.

The results i get are as follows: a significant association seen for recessive genetic model but not for any other model.

My query here is:

i) Is my interpreatation of results correct:
the homozygous variant genotype (AA) has a higher risk of disease as compared to the the heterozygous and homozygous wildtype genotypes (Aa+aa)

ii) homozygous model (AA vs aa) shows no positive results. so are my results for recessive model of any significance.

Any sort of help and suggestions are welcome.

Thanks in advance,
Jasmine




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